Gafe ɲɛnama dɔ min bɛ ADN sinsinni kan

Bluye dekodɔn : ADN sinsinni ye mun ye ?

ADN sinsinni ye fɛɛrɛ ye min bɛ kɛ ka nukilitɔnw sigicogo tigitigi dɔn ADN mɔlikulu kɔnɔ . O nukilitɔnw — adenini (A), timini (T), sitosini (C) ani guanini (G) — olu bɛ kɛ kode kɛrɛnkɛrɛnnen ye min bɛ seliluw bila baara kɛcogo la. Miiri k’a filɛ i n’a fɔ i bɛ lɛtɛrɛw kalan gafe dɔ kɔnɔ min bɛ fɛnɲɛnama dɔ ka ɲɛnamaya kɛcogo ɲɛfɔ. Se min bɛ ADN sinsinni na, o ye fɛn caman sɛmɛntiya, k’a ta furakɛli ni sɛnɛko la, ka taa a bila kiritigɛlaw ni fɛnɲɛnamaw ka fɛnɲɛnamayali la, o kɛra sababu ye ka dɔnnikɛlaw dɛmɛ u ka se ka fɛn caman sɛgɛsɛgɛ jamu kɔnɔ, ka banaw nɔfɛtaama, ani ka an ka jɔli jɔnjɔnw faamu. Nin gafe ɲɛnama in bɛna aw bilasira fɛɛrɛ jɔnjɔnw ni fɛɛrɛ kuraw la minnu b’a to nin ja mikoroskɔpi in kalanni bɛ se ka kɛ.

laboratuwari taama : ka bɔ misali la ka taa ɲɔgɔndan na

Sɛbɛnni kɛcogo bɛ daminɛ laboratuwari la ni fɛnɲɛnamafagalan ye , i n' a fɔ joli walima nɔgɔ . Dɔnniyakɛlaw bɛ ADN bɔ fɔlɔ, ka tila k’a labɛn walasa ka sɛgɛsɛgɛli kɛ. Fɛn min nafa ka bon kosɛbɛ, o ye ka ADN laɲini yɔrɔ kɛrɛnkɛrɛnnenw bonya ni fɛɛrɛ ye min bɛ wele ko Polymerase Chain Reaction (PCR), o min bɛ yɔrɔ kɛrɛnkɛrɛnnen dɔ kopi miliyɔn caman dilan. O bonya in nafa ka bon bawo ɲɔgɔndan masinw mago bɛ ADN hakɛ caman na walasa ka baara kɛ ni min ye. O kɔfɛ, ADN labɛnnen bɛ doni ka don sequencer kɔnɔ. Nin yɔrɔ in de la, yecogo-mago bɛ Kɛ; bi sinsinnanw ka teli ka baara kɛ ni kalali fluorescentw ye, yɔrɔ min na nukilitɔn kelen-kelen bɛɛ (A, T, C, G) bɛ taamasiyɛn kɛ ni yeelen kulɛri wɛrɛ ye. ADN bɛ ka labɛn tuma min na, kamera barikama dɔ bɛ nukilitɔn kelen-kelen bɛɛ faralen kulɛri dɔn, ka o ɲɔgɔndan kalanni nimɔrɔma dɔ jɔ.

kunnafoni faamuyali : Bioinformatique fanga

Bɔli raw min bɛ bɔ sequencer la, o tɛ As, Ts, Cs, ani Gs lisɛli ɲuman ye. O ye kunnafonidilan gɛlɛn ye min bɛ wele ko "kalan" — ADN min bɛ tugu ɲɔgɔn kɔ, o yɔrɔ surunw. O yɔrɔ de la biyoinformatiki bɛ don, porogaramu kɛrɛnkɛrɛnnenw bɛ nin kalan miliyɔn caman ninnu fara ɲɔgɔn kan, u kɛtɔ ka ɲɔgɔndanw sɔrɔ minnu bɛ ɲɔgɔn kan, i n’a fɔ ka jigsaw puzzle belebeleba dɔ ɲɛnabɔ, walasa ka genome dafalen jɔ kokura. O kɔfɛ, o ɲɔgɔndan lajɛlen bɛ suma ni hadamaden ka jamu ye min bɛ tali kɛ a la walasa ka fɛn caman ɲɔgɔnna dɔn. Nin kunnafonidilan gɛlɛn in ɲɛnabɔli nafa ka bon kosɛbɛ. Plateformes i n’a fɔ Mewayz nafa ka bon kosɛbɛ yan, u bɛ baarakɛminɛn modulari di min bɛ ɲininikɛla laboratuwaraw dɛmɛ ka misaliw lajɛ, ka kunnafoniw sigiyɔrɔmali ɲɛnabɔ, ani ka jɛ ka sɛgɛsɛgɛli kɛ k’a sɔrɔ kunnafonidilanw ɲagaminen tɛ min bɛ se ka porozɛ dɔ bila kɔfɛ.

• Misali labɛncogo : ADN bɛ bɔ ka saniya ka bɔ fɛnɲɛnama dɔ la .
• Gafemarayɔrɔ labɛnni : ADN bɛ tila-tila ka adapɛriw fara a kan walasa ka tugu ɲɔgɔn kɔ .
• Sɛbɛnni : gafemarayɔrɔ bɛ doni masin dɔ kɔnɔ min bɛ nukilitɔnw sigicogo kalan .
• Dɔnniya sɛgɛsɛgɛli : biyoinformatiki baarakɛminɛnw bɛ kalanw lajɛ ka tugu ɲɔgɔn kɔ .

ADN sinsinni ye ɲɛnamayako caman tigɛli kɛ ka bɔ ɲɛfɔli dɔnniya la ka kɛ kunnafoniko dɔnniya ye. A b’a to an bɛ se ka ɲɛnamaya yɛrɛ sɔrɔyɔrɔ kalan.

bi baarakɛcogo : sinsinni walew la

Bi sinsinni fɛɛrɛw teliyalen don ani u sɔngɔ ka nɔgɔn ka tɛmɛn fɔlɔ kan , o bɛ na ni baarakɛcogo caman ye . Kɛnɛyako la, dɔgɔtɔrɔw bɛ baara kɛ ni jamu sinsinni ye walasa ka jamu banaw sɛgɛsɛgɛ minnu man ca, ka kansɛri furakɛli kɛ ka kɛɲɛ ni banabagatɔ ka kuru kɛrɛnkɛrɛnnen ye (furakɛcogo min bɛ kɛ a yɛrɛ ta ye), ani ka den kuraw sɛgɛsɛgɛ bana dɔw la. Banakisɛfagalanw na, ɲɔgɔndan kɛli ye dɛmɛ don ka COVID-19 suguya caman jɛnsɛnni kɔlɔsi waati yɛrɛ la. Furakɛcogo kɔfɛ, a bɛ kɛ baganmara jamu la walasa ka fɛnɲɛnama suguya caman nɔfɛtaama ani sɛnɛko la walasa ka sɛnɛfɛnw ladon minnu bɛ se ka muɲu kosɛbɛ. Hakilila minnu bɛ sɔrɔ ɲɔgɔndan na, fanga bɛ olu la, nka u ka kan ka kɛ wale ye. O yɔrɔ de la, sɔrɔw donli baarakɛcogo dɔ kɔnɔ, o ye fɛnba ye. Sɛgɛsɛgɛli laboratuwari kama, ka baara kɛ ni fɛɛrɛ ye i n’a fɔ Mewayz walasa ka ɲɔgɔndan jaabiw ni banabagatɔw ka sɛbɛnw ni kunnafonidiminɛnw cɛsiri, o b’a to kunnafoni nafamaw bɛ na ni latigɛw ye minnu bɛ kɛ ni kunnafoni ye joona.

Siniko ye ɲɔgɔndan ye

ADN sinsinni bɛ taa a fɛ ka wuli ni teliya ye min bɛ mɔgɔ ninakili bɔ . Laɲini min ye ka genome bɛɛ lajɛlen sinsinni kɛ furakɛli kɛcogo kɔrɔ dɔ ye, o bɛ ka kɛ ka taa a fɛ. Ni fɛɛrɛ in bɛ ka taa ɲɛ, gɛlɛya bɛ wuli ka bɔ kunnafonidilanw dilanni na ka taa u ɲɛnabɔli, u kɔrɔfɔli, ani u waleyacogo ɲuman na. Siniɲɛsigi tɛna jɔ ADN kalanni dɔrɔn kan, nka o dɔnniya bɛna don an ka sigidaw n’an ka taabolo la cogo la min tɛ gɛlɛya ye walasa ka sɔrɔli bila senkan ani ka ɲɛnamaya ɲɛ.

Ɲininkali minnu bɛ kɛ tuma caman na

Bluye dekodɔn : ADN sinsinni ye mun ye ?

ADN sinsinni ye fɛɛrɛ ye min bɛ kɛ ka nukilitɔnw sigicogo tigitigi dɔn ADN mɔlikulu kɔnɔ . O nukilitɔnw — adenini (A), timini (T), sitosini (C) ani guanini (G) — olu bɛ kɛ kode kɛrɛnkɛrɛnnen ye min bɛ seliluw bila baara kɛcogo la. Miiri k’a filɛ i n’a fɔ i bɛ lɛtɛrɛw kalan gafe dɔ kɔnɔ min bɛ fɛnɲɛnama dɔ ka ɲɛnamaya kɛcogo ɲɛfɔ. Se min bɛ ADN sinsinni na, o ye fɛn caman sɛmɛntiya, k’a ta furakɛli ni sɛnɛko la, ka taa a bila kiritigɛlaw ni fɛnɲɛnamaw ka fɛnɲɛnamayali la, o kɛra sababu ye ka dɔnnikɛlaw dɛmɛ u ka se ka fɛn caman sɛgɛsɛgɛ jamu kɔnɔ, ka banaw nɔfɛtaama, ani ka an ka jɔli jɔnjɔnw faamu. Nin gafe ɲɛnama in bɛna aw bilasira fɛɛrɛ jɔnjɔnw ni fɛɛrɛ kuraw la minnu b’a to nin ja mikoroskɔpi in kalanni bɛ se ka kɛ.

laboratuwari taama : ka bɔ misali la ka taa ɲɔgɔndan na

Sɛbɛnni kɛcogo bɛ daminɛ laboratuwari la ni fɛnɲɛnamafagalan ye , i n' a fɔ joli walima nɔgɔ . Dɔnniyakɛlaw bɛ ADN bɔ fɔlɔ, ka tila k’a labɛn walasa ka sɛgɛsɛgɛli kɛ. Fɛn min nafa ka bon kosɛbɛ, o ye ka ADN laɲini yɔrɔ kɛrɛnkɛrɛnnenw bonya ni fɛɛrɛ ye min bɛ wele ko Polymerase Chain Reaction (PCR), o min bɛ yɔrɔ kɛrɛnkɛrɛnnen dɔ kopi miliyɔn caman dilan. O bonya in nafa ka bon bawo ɲɔgɔndan masinw mago bɛ ADN hakɛ caman na walasa ka baara kɛ ni min ye. O kɔfɛ, ADN labɛnnen bɛ doni ka don sequencer kɔnɔ. Nin yɔrɔ in de la, yecogo-mago bɛ Kɛ; bi sinsinnanw ka teli ka baara kɛ ni kalali fluorescentw ye, yɔrɔ min na nukilitɔn kelen-kelen bɛɛ (A, T, C, G) bɛ taamasiyɛn kɛ ni yeelen kulɛri wɛrɛ ye. ADN bɛ ka labɛn tuma min na, kamera barikama dɔ bɛ nukilitɔn kelen-kelen bɛɛ faralen kulɛri dɔn, ka o ɲɔgɔndan kalanni nimɔrɔma dɔ jɔ.

kunnafoni faamuyali : Bioinformatique fanga

Bɔli raw min bɛ bɔ sequencer la, o tɛ As, Ts, Cs, ani Gs lisɛli ɲuman ye. O ye kunnafonidilan gɛlɛn ye min bɛ wele ko "kalan" — ADN min bɛ tugu ɲɔgɔn kɔ, o yɔrɔ surunw. O yɔrɔ de la biyoinformatiki bɛ don, porogaramu kɛrɛnkɛrɛnnenw bɛ nin kalan miliyɔn caman ninnu fara ɲɔgɔn kan, u kɛtɔ ka ɲɔgɔndanw sɔrɔ minnu bɛ ɲɔgɔn kan, i n’a fɔ ka jigsaw puzzle belebeleba dɔ ɲɛnabɔ, walasa ka genome dafalen jɔ kokura. O kɔfɛ, o ɲɔgɔndan lajɛlen bɛ suma ni hadamaden ka jamu ye min bɛ tali kɛ a la walasa ka fɛn caman ɲɔgɔnna dɔn. Nin kunnafonidilan gɛlɛn in ɲɛnabɔli nafa ka bon kosɛbɛ. Plateforme minnu bɛ i n’a fɔ Mewayz, olu nafa ka bon yan, u bɛ baarakɛminɛn modulari di min bɛ ɲininikɛla laboratuwaraw dɛmɛ ka misaliw lajɛ, ka kunnafoniw sigiyɔrɔmali ɲɛnabɔ, ani ka jɛ ka sɛgɛsɛgɛli kɛ k’a sɔrɔ kunnafonidilanw ɲagaminen tɛ min bɛ se ka porozɛ dɔ bila kɔfɛ.

bi baarakɛcogo : sinsinni walew la

Bi sinsinni fɛɛrɛw teliyalen don ani u sɔngɔ ka nɔgɔn ka tɛmɛn fɔlɔ kan , o bɛ na ni baarakɛcogo caman ye . Kɛnɛyako la, dɔgɔtɔrɔw bɛ baara kɛ ni jamu sinsinni ye walasa ka jamu banaw sɛgɛsɛgɛ minnu man ca, ka kansɛri furakɛli kɛ ka kɛɲɛ ni banabagatɔ ka kuru kɛrɛnkɛrɛnnen ye (furakɛcogo min bɛ kɛ a yɛrɛ ta ye), ani ka den kuraw sɛgɛsɛgɛ bana dɔw la. Banakisɛfagalanw na, ɲɔgɔndan kɛli ye dɛmɛ don ka COVID-19 suguya caman jɛnsɛnni kɔlɔsi waati yɛrɛ la. Furakɛcogo kɔfɛ, a bɛ kɛ baganmara jamu la walasa ka fɛnɲɛnama suguya caman nɔfɛtaama ani sɛnɛko la walasa ka sɛnɛfɛnw ladon minnu bɛ se ka muɲu kosɛbɛ. Hakilila minnu bɛ sɔrɔ ɲɔgɔndan na, fanga bɛ olu la, nka u ka kan ka kɛ wale ye. O yɔrɔ de la, sɔrɔw donli baarakɛcogo dɔ kɔnɔ, o ye fɛnba ye. Sɛgɛsɛgɛli laboratuwari kama, ka baara kɛ ni sistɛmu ye i n’a fɔ Mewayz walasa ka ɲɔgɔndan jaabiw ni banabagatɔw ka sɛbɛnw ni kunnafonidiminɛnw cɛsiri, o b’a to kunnafoni nafamaw bɛ na ni latigɛw ye minnu bɛ kɛ ni kunnafoni ye joona.

Siniko ye ɲɔgɔndan ye

ADN sinsinni bɛ taa a fɛ ka wuli ni teliya ye min bɛ mɔgɔ ninakili bɔ . Laɲini min ye ka genome bɛɛ lajɛlen sinsinni kɛ furakɛli kɛcogo kɔrɔ dɔ ye, o bɛ ka se ka sɔrɔ ka taa a fɛ. Ni fɛɛrɛ in bɛ ka taa ɲɛ, gɛlɛya bɛ wuli ka bɔ kunnafonidilanw dilanni na ka taa u ɲɛnabɔli, u kɔrɔfɔli, ani u waleyacogo ɲuman na. Siniɲɛsigi tɛna jɔ ADN kalanni dɔrɔn kan, nka o dɔnniya bɛna don an ka sigidaw n’an ka taabolo la cogo la min tɛ gɛlɛya ye walasa ka sɔrɔli bila senkan ani ka ɲɛnamaya ɲɛ.